Compound ID | 3639
Compound 3n
Synonym(s): 1-(2-methyl-5-nitroimidazol-1-yl)propan-2-yl (E)-3-(4-phenylphenyl)prop-2-enoate | secnidazole derivative 3n
Class: Small molecule antibacterial agent
| Agent Type: | Semisynthetic; Small molecule; Direct acting; |
| Spectrum of activity: | Gram-positive & Gram-negative |
| Mechanism of action: | Fatty acid synthesis inhibitor. FabH inhibitor (Fatty acid biosynthesis: 3-oxoacyl-[acyl-carrier-protein] synthase III inhibitor) |
| Target Pathogen: | Active against Staphylococcus aureus and Escherichia coli |
| Description: | Semisynthetic compound derived from cinnamic acid and secnidazole scaffold |
| Institute where first reported: | Nanjing University, PR China |
| Year first mentioned: | 2011 |
| Development status: | Experimental |
| External links: | |
| Structure link: | https://pubchem.ncbi.nlm.nih.gov/compound/53357207 |
| Citation: | https://www.sciencedirect.com/science/article/pii/S0968089611004494?via%3Dihub |
| Patent: | CN102675211 A |
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