Compound ID | 3642

Update compound information

CCp1

Synonym(s): 3-{5-[3-Methyl-5-(methylamino)phenyl]furo[2,3-d]pyrimidin-6-yl}phenol

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: GlmU (UDP-N-acetylglucosamine phosphorylase) inhibitor, but also reported to inhibit DNA gyrase, 30S RNA molecules, and OmpF porins
Target Pathogen: Active against Staphylococcus aureus and Escherichia coli
Description: Natural product from Actinomadura sp. AL2; has a furopyrimidine scaffold
Institute where first reported: North-Eastern Hill University, Shillong, India
Year first mentioned: 2017
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight:
Iso. SMILES: CNc1cc(C)cc(c1)c2c(oc3ncncc23)c4cccc(O)c4
InChI Key: PKLJETLKFUSBOL-UHFFFAOYSA-N
Can. SMILES: CC1=CC(=CC(=C1)C2=C(C3=CC(=CC=C3)O)OC4=NC=NC=C24)NC
InChI: InChI=1S/C20H17N3O2/c1-12-6-14(8-15(7-12)21-2)18-17-10-22-11-23-20(17)25-19(18)13-4-3-5-16(24)9-13/h3-11,21,24H,1-2H3
External links:
Structure link: https://pubchem.ncbi.nlm.nih.gov/compound/132278221
Citation: https://link.springer.com/article/10.1007/s11274-017-2343-1

AntibioticDB is supported by GARDP.

If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.