Compound ID | 3647

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Beta-chloroalanyl-beta-chloroalanine

Class: Antimicrobial peptide

Agent Type: Synthetic; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Cell wall synthesis inhibitor. Alanine racemase inhibitor
Target Pathogen: Active against Staphylococcus aureus, Streptococcus agalactiae, Escherichia coli and Haemophilus influenzae (only Gram-negatives it is active against)
Description: Synthetic compound; both di- and tri-peptide derivatives of beta-chloroalanyl show broad spectrum antibacterial activity
Institute where first reported: University of Chicago USA
Year first mentioned: 1986
Development status: Experimental
Chemical structure(s):
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Molecular weight:
Iso. SMILES: C([C@@H](C(=O)N[C@@H](CCl)C(=O)O)N)Cl
InChI Key: VFVOOLWBPFEFKL-IMJSIDKUSA-N
Can. SMILES: C([C@@H](C(=O)N[C@@H](CCl)C(=O)O)N)Cl
InChI: InChI=1S/C6H10Cl2N2O3/c7-1-3(9)5(11)10-4(2-8)6(12)13/h3-4H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-/m0/s1
External links:
Structure link: https://pubchem.ncbi.nlm.nih.gov/compound/135897
Citations:
  • https://www.sciencedirect.com/science/article/pii/S0021925819574841?via%3Dihub
  • https://pubs.acs.org/doi/abs/10.1021/jm00160a045

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