Compound ID | 3649

Update compound information

APY409

Synonym(s): APY-409  |  APY 409

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive, Gram-negative & Antimycobacterial
Mechanism of action: RNA synthesis inhibitor. RNA polymerase inhibitor; binding site distinct to rifampin and fidaxomicin
Combined with other compounds: Yes
Propensity to select resistant mutants: Yes
Description: Synthetic compound; an arylmyxopyronin scaffold
Institute where first reported: Rutgers University
Year first mentioned: 2025
Highest developmental phase: Preclinical
Development status: Experimental
Chemical structure(s):
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Molecular weight:
Iso. SMILES: O=C1C(C(/C(C)=C/C2=C(Cl)N=C(OC3=CC(F)=C(F)C=C3)S2)=O)=C([O-])C=C(CCC/C=C/NC(OC([2H])([2H])[2H])=O)O1.[Na+]
InChI Key: WCRXPCQYKFARKY-QYFIOOTQSA-M
Can. SMILES: C/C(=C\C1=C(Cl)N=C(OC2=CC=C(C(=C2)F)F)S1)/C(=O)C3=C(C=C(CCC/C=C/NC(=O)OC([2H])([2H])[2H])OC3=O)[O-].[Na+]
InChI: InChI=1S/C25H21ClF2N2O7S.Na/c1-13(10-19-22(26)30-25(38-19)37-15-7-8-16(27)17(28)11-15)21(32)20-18(31)12-14(36-23(20)33)6-4-3-5-9-29-24(34)35-2;/h5,7-12,31H,3-4,6H2,1-2H3,(H,29,34);/q;+1/p-1/b9-5+,13-10+;/i2D3;
External links:
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/21862392/
  • https://patents.google.com/patent/US9592221B2/en?inventor=Richard+Ebright&oq=Richard+Ebright
  • https://pubmed.ncbi.nlm.nih.gov/18957204/
    • Patent: US9592221B2

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