Compound ID | 3652
D-GL13K
Synonym(s): DGL13K | D GL13K
Class: Antimicrobial peptide
| Agent Type: | Semisynthetic; |
| Spectrum of activity: | Gram-positive & Gram-negative |
| Mechanism of action: | Unknown |
| Target Pathogen: | Active against methicillin-resistant Staphylococcus aureus, Enterococcus faecium, Enterococcus faecalis, Streptococcus gordonii, Acinetobacter baumannii, Clostridium difficile, Enterobacter cloacae, Escherichia coli, Klebsiella sp., and multidrug- and extensively drug-resistant Pseudomonas aeruginosa |
| Propensity to select resistant mutants: | No |
| Description: | Semisynthetic compound; D-enantiomer of GL13K derived from human salivary protein; a 13-amino acid; has been extensively tested in vitro and in animal models, including mouse skin infection and human skin explant models; not susceptible to proteases; eradicates biofilm |
| Institute where first reported: | Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, Minnesota, United States of America |
| Year first mentioned: | 2018 |
| Development status: | Experimental |
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