Compound ID | 3657

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APY-GNGP1

Synonym(s): APY GNGP1

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: RNA synthesis inhibitor. RNA polymerase inhibitor; binding site distinct to rifampin and fidaxomicin
Target Pathogen: Active against Acinetobacter, Burkholderia, Staphylococccus, Streptococcus, Enterococcus, and respiratory atypical pathogens including drug-resistant and multi-drug-resistant strains
Description: Synthetic compound; a myxopyronin-type antibiotic with arylmyxopyronin scaffold; compound related to natural products myxopyronin A and myxopyronin B; orally available; shows >2-log reduction in neutropenic mouse lung methicillin-resistant Staphylococcus aureus infection model
Institute where first reported: Rutgers University
Year first mentioned: 2025
Highest development stage: Preclinical
Development status: Experimental
Chemical structure(s):
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Molecular weight:
Iso. SMILES: O=C1C(C(/C(/C)=C/C2=C(Cl)N=C(OC3=CC(F)=C(F)C=C3)S2)=O)=C(O)C=C(CCC/C=C/NC(OC)=O)O1
InChI Key: FCTVYBQZUCDURJ-VJXHFHOESA-N
Can. SMILES: C/C(=C\C1=C(Cl)N=C(OC2=CC=C(C(=C2)F)F)S1)/C(=O)C3=C(C=C(CCC/C=C/NC(=O)OC)OC3=O)O
InChI: InChI=1S/C25H21ClF2N2O7S/c1-13(10-19-22(26)30-25(38-19)37-15-7-8-16(27)17(28)11-15)21(32)20-18(31)12-14(36-23(20)33)6-4-3-5-9-29-24(34)35-2/h5,7-12,31H,3-4,6H2,1-2H3,(H,29,34)/b9-5+,13-10+
External links:
Citations:
  • https://doi.org/10.1016/j.mib.2011.07.030
  • https://doi.org/10.1016/j.cell.2008.09.033
    • Patent: WO/2025/177774

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