Compound ID | 3659

Update compound information

REDX05777

Synonym(s): REDX 05777  |  REDX-05777

Class: DNA synthesis inhibitor

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive, Gram-negative & Antimycobacterial
Mechanism of action: DNA synthesis inhibitor. DNA gyrase inhibitor and topoisomerase IV inhibitor
Target Pathogen: Broad spectrum activity with greater potency against Gram-positive bacteria
Description: A novel bacterial topoisomerase inhibitor (NBTI) with tricyclic northern head group
Institute where first reported: Redx Pharma, Alderley Park, Cheshire, United Kingdom
Year first mentioned: 2016
Development status: Experimental
Chemical structure(s):
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Molecular weight:
Iso. SMILES: O=C1N(CCN2CCC(NCC3=NC=4NC(COC4C=C3)=O)CC2)C5=CC(F)=CC=C5C6=C1N=CO6
InChI Key: XIFPCAXFYWCWNF-UHFFFAOYSA-N
Can. SMILES: C1=CC2=C(C=C1F)N(CCN3CCC(CC3)NCC4=CC=C5C(=N4)NC(=O)CO5)C(=O)C6=C2OC=N6
InChI: InChI=1S/C25H25FN6O4/c26-15-1-3-18-19(11-15)32(25(34)22-23(18)36-14-28-22)10-9-31-7-5-16(6-8-31)27-12-17-2-4-20-24(29-17)30-21(33)13-35-20/h1-4,11,14,16,27H,5-10,12-13H2,(H,29,30,33)
External links:
Citation: https://doi.org/10.1128/AAC.02100-16
Patent: WO 2016/024096

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