Compound ID | 3660

Update compound information

REDX06276

Synonym(s): REDX 06276  |  REDX-06276

Class: DNA synthesis inhibitor

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: DNA synthesis inhibitor. DNA gyrase inhibitor and topoisomerase IV inhibitor
Target Pathogen: Active against Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, and Acinetobacter baumannii
Propensity to select resistant mutants:
Description: A novel bacterial topoisomerase inhibitor with tricyclic northern head group
Institute where first reported: Redx Pharma, Alderley Park, Cheshire, United Kingdom
Year first mentioned: 2016
Development status: Experimental
Chemical structure(s):
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Molecular weight:
Iso. SMILES: O=C1N(CCN2CCC(NCC3=NC=4NC(COC4C=C3)=O)CC2)C5=CC(F)=CC=C5C6=CON=C16
InChI Key: YQXAYIPPIHWCKZ-UHFFFAOYSA-N
Can. SMILES: C1=CC2=C(C=C1F)N(CCN3CCC(CC3)NCC4=CC=C5C(=N4)NC(=O)CO5)C(=O)C6=NOC=C26
InChI: InChI=1S/C25H25FN6O4/c26-15-1-3-18-19-13-36-30-23(19)25(34)32(20(18)11-15)10-9-31-7-5-16(6-8-31)27-12-17-2-4-21-24(28-17)29-22(33)14-35-21/h1-4,11,13,16,27H,5-10,12,14H2,(H,28,29,33)
External links:
Citation: https://doi.org/10.1128/AAC.02100-16

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