Compound ID | 3667

Update compound information

1-{3-[(4-Cyclopentanecarbonylpiperazin-1-yl)sulfonyl]phenyl}-3-(1,3-thiazol-2-yl)urea

Synonym(s): RefChem:422991

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Protein synthesis inhibitor. PheRS inhibitor (phenylalanyl-tRNA synthetase).
Target Pathogen: Escherichia coli; Haemophilus influenzae; Moraxella catarrhalis; Staphylococcus aureus; Streptococcus pneumoniae
Institute where first reported: Bayer A.-G.
Year first mentioned: 2003
Highest development stage: Preclinical
Development status: Unknown
Chemical structure(s):
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Molecular weight: 463.58
Iso. SMILES: O=C(NC1=CC=CC(=C1)S(=O)(=O)N2CCN(CC2)C(=O)C3CCCC3)NC4=NC=CS4
InChI Key: SPEJDCTWLFPQCS-UHFFFAOYSA-N
Can. SMILES: C1CCC(C1)C(=O)N2CCN(CC2)S(=O)(=O)C3=CC(=CC=C3)NC(=O)NC4=NC=CS4
InChI: InChI=1S/C20H25N5O4S2/c26-18(15-4-1-2-5-15)24-9-11-25(12-10-24)31(28,29)17-7-3-6-16(14-17)22-19(27)23-20-21-8-13-30-20/h3,6-8,13-15H,1-2,4-5,9-12H2,(H2,21,22,23,27)
External links:
Structure link: https://pubchem.ncbi.nlm.nih.gov/compound/12087504
Citation: https://doi.org/10.1128/aac.48.2.525-532.2004
Patent: DE10155684

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