Compound ID | 3669

Update compound information

(1R)-N-[(5-methyl-1H-indol-2-yl)methyl]-1-naphthalen-1-ylethanamine

Synonym(s): CHEMBL3754049  |  SCHEMBL10039779

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Unknown
Target Pathogen: Staphylococcus aureus; Escherichia coli; Klebsiella pneumoniae; Pseudomonas aeruginosa; Streptococcus pneumoniae
Description: Indole-derived antibacterial chemical series disclosed by CNRS/Aix-Marseille University, demonstrating broad-spectrum activity against Gram-positive bacteria, with weaker activity observed against select Gram-negative pathogens.
Institute where first reported: Aix Marseille Universite; Centre National de la Recherche Scientifique CNRS
Year first mentioned: 2010
Highest development stage: Discovery
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 314.42
Iso. SMILES: C[C@@H](NCC1=CC2=CC(C)=CC=C2N1)C3=CC=CC4=CC=CC=C34
InChI Key: YIWWEJRUVJWHCH-MRXNPFEDSA-N
Can. SMILES: CC1=CC2=C(C=C1)NC(=C2)CN[C@H](C)C3=CC=CC4=C3C=CC=C4
InChI: InChI=1S/C22H22N2/c1-15-10-11-22-18(12-15)13-19(24-22)14-23-16(2)20-9-5-7-17-6-3-4-8-21(17)20/h3-13,16,23-24H,14H2,1-2H3/t16-/m1/s1
External links:
Structure link: https://pubchem.ncbi.nlm.nih.gov/compound/57385592
Citation: https://worldwide.espacenet.com/patent/search/family/043735134/publication/WO2012084971A1?q=WO2012084971A1
Patent: WO2012084971A1

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