Compound ID | 3670

Update compound information

3-benzyl-6-(4-methylpiperazin-1-yl)sulfonyl-1H-benzimidazol-2-one

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Unknown
Target Pathogen: Pseudomonas aeruginosa; Staphylococcus aureus; Streptococcus pyogenes
Description: Benzimidazol-2-one derivative antibacterial scaffold with sulfonyl-piperazine substitution pattern showing broad-spectrum antibacterial activity.
Institute where first reported: Sichuan Provincial People's Hospital
Year first mentioned: 2015
Highest development stage: Discovery
Development status: Experimental
Chemical structure(s):
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Molecular weight: 386.47
Iso. SMILES: CN1CCN(CC1)S(=O)(=O)C2=CC=C3N(CC4=CC=CC=C4)C(=O)NC3=C2
InChI Key: AAWHTAVQIBQIMU-UHFFFAOYSA-N
Can. SMILES: CN1CCN(CC1)S(=O)(=O)C2=CC=C3C(=C2)NC(=O)N3CC4=CC=CC=C4
InChI: InChI=1S/C19H22N4O3S/c1-21-9-11-22(12-10-21)27(25,26)16-7-8-18-17(13-16)20-19(24)23(18)14-15-5-3-2-4-6-15/h2-8,13H,9-12,14H2,1H3,(H,20,24)
External links:
Structure link: https://pubchem.ncbi.nlm.nih.gov/compound/132525565
Citation: https://patents.google.com/patent/CN106798740B/en?oq=CN106798740B
Patent: CN106798740B

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