Tacapenem

Synonym(s): R-95867

Class: Beta-lactam (cephalosporin)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	R-95867 is a broad spectrum antibiotic which is highly stable to β-lactamases
Institute where first reported:	Sankyo, Japan
Year first mentioned:	1996
Highest developmental phase:	Phase 2
Development status:	Inactive

Chemical structure(s):
Canonical SMILES:	C[C@@H]1[C@@H]2[C@@H]([C@@H](C)O)C(=O)N2C(=C1S[C@@H]3CC(=O)NC3)C(=O)O
Isomeric SMILES:	C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1S[C@@H]3CC(=O)NC3)C(=O)O)[C@@H](C)O
InChI:	InChI=1S/C14H18N2O5S/c1-5-10-9(6(2)17)13(19)16(10)11(14(20)21)12(5)22-7-3-8(18)15-4-7/h5-7,9-10,17H,3-4H2,1-2H3,(H,15,18)(H,20,21)/t5-,6-,7-,9-,10-/m1/s1
InChI Key:	CTEFNVKDRWMZSL-CTNSIQBBSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/73302

External links:
Guide to Pharmacology:	tacapenem
Citations:	http://jac.oxfordjournals.org/content/42/4/427 https://academic.oup.com/jac/article/45/3/357/835936?searchresult=1