Compound ID | 377
SKF 104662
Synonym(s): SKF104662 | SKF-104662
Class: Glycopeptide
| Agent Type: | Semisynthetic; |
| Spectrum of activity: | Gram-positive |
| Mechanism of action: | Unknown |
| Target Pathogen: | Broad Gram-positive activity |
| Description: | Semisynthetic compound derived from a glycopeptide produced by Streptomyces manoorii |
| Institute where first reported: | SmithKline Beecham; GSK |
| Year first mentioned: | 1988 |
| Highest development stage: | Phase 1 |
| Development status: | Inactive |
| Reason dropped: | Activity very similar to vancomycin and teicoplanin, very little is known about this. Either unpublished data or wasn't promising in terms of passing non-inferior tests or superiority. From ICAAC, 1984, 1988, animal trials in mice showed reduced toxic potential compared to vancomycin. |
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