Tirandalydigin

Class: Beta-lactam (penem)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Bacterial DNA-directed RNA polymerase; structurally similar to both tirandamycin and streptolydigin. Potent against a number of anaerobes.
Institute where first reported:	Abbott Laboratories, USA
Year first mentioned:	1987
Highest developmental phase:	Preclinical
Development status:	Inactive

Chemical structure(s):
Canonical SMILES:	C/C(=C\[C@@H](C)[C@@H]1[C@@H](C)[C@H]2C=CC3(CO3)[C@](C)(O2)O1)/C=C/C(=C/4\C(=O)CNC4=O)/O
Isomeric SMILES:	C[C@H]1[C@H]2C=CC3(CO3)[C@](O2)(O[C@@H]1[C@H](C)/C=C(\C)/C=C/C(=C/4\C(=O)CNC4=O)/O)C
InChI:	InChI=1S/C22H27NO6/c1-12(5-6-15(24)18-16(25)10-23-20(18)26)9-13(2)19-14(3)17-7-8-22(11-27-22)21(4,28-17)29-19/h5-9,13-14,17,19,24H,10-11H2,1-4H3,(H,23,26)/b6-5+,12-9+,18-15-/t13-,14+,17-,19-,21-,22?/m1/s1
InChI Key:	LTYHWFXVSQHTQH-BWPJEIAHSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/54717174

External links:
Guide to Pharmacology:	tirandalydigin
Citation:	http://www.ncbi.nlm.nih.gov/pubmed/1517158