Compound ID | 39
NAI-603
Synonym(s): VIC 200603 | VIC 603
Class: Antimicrobial peptide
| Agent Type: | Semisynthetic; Direct acting; |
| Spectrum of activity: | Gram-positive |
| Mechanism of action: | Cell wall synthesis inhibitor. Binds to lipid II |
| Target Pathogen: | Active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus sp., Enterococcus faecalis, and Clostridium difficile |
| Propensity to select resistant mutants: | Yes |
| Description: | Semisynthetic compound derived from natural product ramoplanin; well-tolerated in mouse septicaemia models infected with MRSA; shows superior efficacy to vancomycin and teicoplanin; a glycolipodepsipeptide |
| Institute where first reported: | NAICONS, Milan, Italy |
| Year first mentioned: | 2014 |
| Development status: | Experimental |
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