Compound ID | 399
NZ2114
Class: Antimicrobial peptide
| Agent Type: | Semisynthetic; Direct acting; |
| Spectrum of activity: | Gram-positive |
| Mechanism of action: | Cell wall synthesis inhibitor. Lipid II inhibitor |
| Description: | Semisynthetic compound derived from the natural product plectasin; a defensin-like cationic antimicrobial peptide; 1. Nielsen LA, Ravn BT, Lichtenberg J, et al. In vivo profiling of plectasin variant NZ2114, a novel promising antimicrobial peptide. 47th-ICAAC-2007 2007;243 2. Sandvang D, Mygind PH, Jones ME, et al. In vitro activity and characterization of NZ2114: an improved variant of plectasin. 47th-ICAAC-2007 2007;243 |
| Institute where first reported: | Novozymes A/S, Denmark; Sanofi Aventis, France |
| Year first mentioned: | 2007 |
| Highest development stage: | Preclinical |
| Development status: | Experimental |
| External links: | |
| Citations: |
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