Compound ID | 403

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Mureidomycin B

Class: MraY inhibitor

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Interferes with cell-wall synthesis by inhibiting transfer of the peptidoglycan precursor moiety (MurNAc-pentapeptide) to the membrane lipid carrier, undecaprenyl phosphate.
Description: Uridyl peptide
Institute where first reported: Sankyo Co. Ltd, Japan
Year first mentioned: 1991
Development status: Inactive
Reason Dropped: Rapid resistance due to transport loss (LS)
Chemical structure(s):
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Molecular weight: 842.92
Iso. SMILES: CC(C(C(=O)N/C=C/1\CC(C(O1)N2CCC(=O)NC2=O)O)NC(=O)C(CCSC)NC(=O)NC(CC3=CC(=CC=C3)O)C(=O)O)N(C)C(=O)C(CC4=CC(=CC=C4)O)N
InChI Key: DXBJHRPKFQGVGZ-NCELDCMTSA-N
Can. SMILES: CC(C(C(=O)N/C=C/1\CC(C(N2CCC(=O)NC2=O)O1)O)NC(=O)C(CCSC)NC(=O)NC(CC3=CC=CC(=C3)O)C(=O)O)N(C)C(=O)C(CC4=CC=CC(=C4)O)N
InChI: InChI=1S/C38H50N8O12S/c1-20(45(2)34(53)26(39)16-21-6-4-8-23(47)14-21)31(33(52)40-19-25-18-29(49)35(58-25)46-12-10-30(50)43-38(46)57)44-32(51)27(11-13-59-3)41-37(56)42-28(36(54)55)17-22-7-5-9-24(48)15-22/h4-9,14-15,19-20,26-29,31,35,47-49H,10-13,16-18,39H2,1-3H3,(H,40,52)(H,44,51)(H,54,55)(H2,41,42,56)(H,43,50,57)/b25-19+
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/substance/49895352
Citation:

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