Compound ID | 406
Pyrazolidinedione series - Wyeth
Synonym(s): 1,2-bis(4-chlorophenyl)-3,5-dioxopyrazolidine-4-carboxamide
Class: Small molecule antibacterial agent
| Agent Type: | Synthetic; Small molecule; Direct acting; |
| Spectrum of activity: | Gram-positive |
| Mechanism of action: | Cell wall synthesis inhibitor. MurB inhibitor |
| Target Pathogen: | Active against vancomycin-resistant Enterococcus sp. and methicillin-resistant Staphylococcus aureus |
| Description: | Yang Y, Severin A, Singh G, et al. Identification of novel pyrazolidinediones as inhibitors of bacterial cell wall synthesis, targeting MurB, the Enopyruval-UDP-N-acetyl-glucosamine reductase. 43rd-ICAAC 2003;271 |
| Institute where first reported: | Wyeth Research (Pfizer, USA) |
| Year first mentioned: | 2003 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://journals.asm.org/doi/10.1128/aac.50.2.556-564.2006 |
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