Compound ID | 408

Update compound information

SC-44942-A

Class: Cell-wall synthesis inhibitor (quinoxaline)

Details of activity: Active against a broad spectrum of anaerobic bacteria but inactive against Campylobacter jejuni. This was also less active against C. difficile than Campylobacter jejuni.
Description: Segreti J, Goodman LJ, Kerns L, et al. In vitro activity of two new quinoxaline compounds against Campylobacter sp. and Clostridium difficile. 31st-ICAAC 1991;161.
Institute where first reported: Searle Pharm. (Pharmacia Corporation, USA)
Year first mentioned: 1991
Highest developmental phase: Preclinical
Development status: Inactive
Reason Dropped: Likely to have not been continued due to being less active than others in the series
Chemical structure(s):
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Molecular weight: 409.83
Iso. SMILES: CC1(CN=C2C(=[N+](C3=C(N2C1)C=CC(=C3)C(F)(F)F)[O-])C4=CC=CC=C4)C.Cl
InChI Key: MFLKIPORVXKXSO-UHFFFAOYSA-N
Can. SMILES: CC1(C)CN=C2C(=[N+](C3=C(C=CC(=C3)C(F)(F)F)N2C1)[O-])C4=CC=CC=C4.Cl
InChI: InChI=1S/C20H18F3N3O.ClH/c1-19(2)11-24-18-17(13-6-4-3-5-7-13)26(27)16-10-14(20(21,22)23)8-9-15(16)25(18)12-19;/h3-10H,11-12H2,1-2H3;1H
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/3082689
Citation: https://www.sciencedirect.com/science/article/pii/0732889393900312?via%3Dihub

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