Compound ID | 409
LY228238
Class: Beta-lactam
| Agent Type: | Semisynthetic; Small molecule; Direct acting; |
| Spectrum of activity: | Gram-positive & Gram-negative |
| Mechanism of action: | Cell wall synthesis inhibitor |
| Description: | Cephem-type; KASHER, J. S.; J. A. EUDALY, R. JOHNSON & J. SHOUFLER: Pharmacokinetics of orally absorbed beta-lactam antibiotics LY228238 and LY257128 in laboratory animals. Program and Abstracts of the 28th Intersci. Conf. on Antimicrob. Agents Chemother., No. 535, p. 202, Los Angeles, Oct. 23-26, 1988 |
| Institute where first reported: | Eli Lilly, USA |
| Year first mentioned: | 1988 |
| Highest development stage: | Preclinical |
| Development status: | Experimental |
| Reason dropped: | Low oral bioactivity in monkeys compared with rats and mice |
| External links: | |
| Citation: | https://doi.org/10.7164/antibiotics.42.1653 |
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