E1010 (ER-35786)

Class: Beta-lactam (carbapenem)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Antipseudomonal activity
Description:	Sato N, Sasho M, Kamada A, et al. ER-35786, a new anti-pseudomonal carbapenem I. synthesis and structure activity relations or 2-substituted 1β-methyl carbapenems. 35th-Intersci-Conf-Antimicrobial-Agents-Chemother 1995; 139.
Institute where first reported:	Eisai Co Ltd
Year first mentioned:	1995
Highest developmental phase:	Phase 1
Development status:	Inactive

Chemical structure(s):
Canonical SMILES:	C[C@@H]1[C@@H]2[C@@H]([C@@H](C)O)C(=O)N2C(=C1S[C@H]3C[C@@H]([C@@H]([C@@H]4CCNC4)O)NC3)C(=O)O.Cl
Isomeric SMILES:	C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1S[C@H]3C[C@H](NC3)[C@@H]([C@@H]4CCNC4)O)C(=O)O)[C@@H](C)O.Cl
InChI:	InChI=1S/C19H29N3O5S.ClH/c1-8-14-13(9(2)23)18(25)22(14)15(19(26)27)17(8)28-11-5-12(21-7-11)16(24)10-3-4-20-6-10;/h8-14,16,20-21,23-24H,3-7H2,1-2H3,(H,26,27);1H/t8-,9-,10-,11+,12+,13-,14-,16-;/m1./s1
InChI Key:	WRVJTXDJDKITNK-XNGFCKKMSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/6918311

External links:
Guide to Pharmacology:	E-1010 free base
Main Source:	https://journals.asm.org/doi/10.1128/aac.41.2.298