Compound ID | 421
A54145 complex
Class: Lipopeptide
| Agent Type: | Natural product; |
| Spectrum of activity: | Gram-negative |
| Mechanism of action: | Unknown |
| Description: | Natural product from Streptomyces fradiae and Streptomyces refuineus ssp. thermotolerans |
| Institute where first reported: | Eli Lilly, US |
| Year first mentioned: | 1988 |
| Development status: | Experimental |
| Reason dropped: | Transient resistance build up through passing Streptococcus sp. 7 times at sublethal concentrations and demonstrates acute mouse toxicity (ICAAC 1988, no.971). |
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