Compound ID | 421

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A54145 complex

Class: Lipopeptide

Spectrum of activity: Gram-negative
Institute where first reported: Eli Lilly, US
Year first mentioned: 1988
Highest developmental phase: Preclinical
Development status: Inactive
Reason Dropped: Transient resistance build up through passing Streptococcus sp. 7 times at sublethal concentrations and demonstrates acute mouse toxicity (ICAAC 1988, no.971).
External links:
Citations:
  • https://www.jstage.jst.go.jp/article/antibiotics1968/43/6/43_6_601/_article
  • http://www.ncbi.nlm.nih.gov/pubmed/2380110
  • https://www.jstage.jst.go.jp/article/antibiotics1968/43/6/43_6_601/_pdf/-char/en

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