Compound ID | 427

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KST 150,257

Synonym(s): KST-150,257  |  KST 150257

Class: Beta-lactam

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Cell wall synthesis inhibitor
Description: Cephalosporin-type; Park SH, Park SY, Kim DY, et al. Novel 3-isoxazolylvinyl Cephalosporins: II. Antibacterial activities against clinical isolates and pharmacokinetics in mice. 37th-Intersci-Conf-Antimicrobial-Agents-Chemother 1997; 177.
Institute where first reported: Parke Davis Pharmaceutical Research (Pfizer, USA)
Year first mentioned: 1997
Development status: Experimental
Chemical structure(s):
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Molecular weight: 518.89
Iso. SMILES: C1C(=C(N2C(S1)C(C2=O)NC(=O)/C(=N\O)/C3=CSC(=N3)N)C(=O)[O-])/C=C/C4=CC(=NO4)Cl.[Na+]
InChI Key: RXHGOBOGBLFWCE-HWQCDBSUSA-M
Can. SMILES: C(=C\C1=CC(=NO1)Cl)/C2=C(C(=O)[O-])N3C(=O)C(C3SC2)NC(=O)/C(=N\O)/C4=CSC(=N4)N.[Na+]
InChI: InChI=1S/C17H13ClN6O6S2.Na/c18-9-3-7(30-23-9)2-1-6-4-31-15-11(14(26)24(15)12(6)16(27)28)21-13(25)10(22-29)8-5-32-17(19)20-8;/h1-3,5,11,15,29H,4H2,(H2,19,20)(H,21,25)(H,27,28);/q;+1/p-1/b2-1+,22-10-;
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/23693945
Citation: https://doi.org/10.1086/514929

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