Compound ID | 431
MC-02,331
Class: Beta-lactam (cephalosporin)
| Spectrum of activity: | Gram-positive |
| Details of activity: | Mice infected with S. aureus, were treated with ampicillin (100mg/kg), vancomycin (30mg/kg) or MC-02331 (1, 10 and 30mg/kg). MC-02331 was more active than both vancomycin and ampicillin |
| Combined with other compounds: | In combination with gentamicin, MC-02331 worked synergistically to kill gentamicin susceptible enterococci. |
| Description: | Griffith D, Annamalai T, et al. In vivo pharmacology of MC-02331, a new Cephalosporin active against multi-resistant gram-positive organisms. 36th-Intersci-Conf-Antimicrobial-Agents-Chemother 1996;124 |
| Institute where first reported: | Microcide Pharmaceuticals (Essential Therapeutics [Ceased]) |
| Year first mentioned: | 1996 |
| Highest developmental phase: | Preclinical |
| Development status: | Inactive |
| External links: | |
| PubChem link: | https://pubchem.ncbi.nlm.nih.gov/substance/275532862 |
| Citation: |
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