Compound ID | 438

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RU 59863

Class: Beta-lactam

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Cell wall synthesis inhibitor
Description: Catechol cephalosporin-type; 1. Le Noc O, Bryskier A and Champelovier D. Comparative antibacterial activity of RU 59863, a new catechol Cephalosporin, and new C-3' quaternary ammonium Cephalosporins. 35th-Intersci-Conf-Antimicrobial-Agents-Chemother 1995; 123. 2. Erwin ME and Jones RN. In vitro activity of RU-59863, a new catechol containing Cephalosporin Cephalosporin of antimicrobial agent. 36th-Intersci-Conf-Antimicrobial-Agents-Chemother 1996; 125.
Institute where first reported: Hoechst Marion Roussel (Aventis, France)
Year first mentioned: 1994
Development status: Experimental
Chemical structure(s):
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Molecular weight: 722.72
Iso. SMILES: NC1=SC(/C(/C(N[C@H]2C(N3[C@@H]2SCC(/C=C/C[N+]4=CC=CC5=C4C=CC=C5)=C3C([O-])=O)=O)=O)=N/O[C@@H](C6=CC(F)=C(O)C(O)=C6)C(O)=O)=CN1
InChI Key: PVENFBCNIANEQL-FMQUDGBJSA-N
Can. SMILES: C1=CC2=C(C=C1)[N+](=CC=C2)C/C=C/C3=C(C(=O)[O-])N4C(=O)[C@@H]([C@H]4SC3)NC(=O)/C(=N\O[C@@H](C5=CC(=C(C(=C5)F)O)O)C(=O)O)/C6=CNC(=S6)N
InChI: InChI=1S/C32H27FN6O9S2/c33-18-11-17(12-20(40)25(18)41)26(31(46)47)48-37-22(21-13-35-32(34)50-21)27(42)36-23-28(43)39-24(30(44)45)16(14-49-29(23)39)7-4-10-38-9-3-6-15-5-1-2-8-19(15)38/h1-9,11-13,23,26,29,50H,10,14H2,(H7-,34,35,36,37,40,41,42,44,45,46,47)/b7-4+/t23-,26-,29+/m0/s1
External links:
Citations:
  • https://www.sciencedirect.com/science/article/pii/S0732889397000047?via%3Dihub
  • https://doi.org/10.1016/S0732-8893(97)00004-7

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