Compound ID | 441

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YM-40220

Class: Beta-lactam

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Cell wall synthesis inhibitor
Description: Cephalosporin with (dimethylisoxazolidinio)vinyl group; Hara R, Sakamoto K, Itahana H, et al. YM-40220, a new parenteral Cephalosporin: I. synthesis and structure-activity relationships of 3-(2,2-dimethyl-5-isoxazolidinio)- vinyl Cephalosporins. 34th-Intersci-Conf-Antimicrobial-Agents-Chemother 1994; 161.
Institute where first reported: Yamanouchi, Japan
Year first mentioned: 1994
Development status: Experimental
Chemical structure(s):
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Molecular weight: 527.55
Iso. SMILES: C[N+]1(C)CC[C@H](O1)/C=C/C2=C(N3[C@H](SC2)[C@H](NC(=O)/C(=N\OCF)/C4=NSC(N)=N4)C3=O)C(=O)[O-]
InChI Key: WJJOCNKPKYTMLI-BQCINXSWSA-N
Can. SMILES: C[N+]1(C)CC[C@@H](/C=C/C2=C(C(=O)[O-])N3C(=O)[C@H]([C@H]3SC2)NC(=O)/C(=N\OCF)/C4=NSC(=N4)N)O1
InChI: InChI=1S/C19H22FN7O6S2/c1-27(2)6-5-10(33-27)4-3-9-7-34-17-12(16(29)26(17)13(9)18(30)31)22-15(28)11(24-32-8-20)14-23-19(21)35-25-14/h3-4,10,12,17H,5-8H2,1-2H3,(H3-,21,22,23,25,28,30,31)/b4-3+,24-11-/t10-,12-,17-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/substance/276003097
Citation: https://www.jstage.jst.go.jp/article/antibiotics1968/49/11/49_11_1162/_pdf/-char/en

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