Compound ID | 444
Class: Beta-lactam (cephalosporin)
Spectrum of activity: | Gram-positive & Gram-negative |
Details of activity: | Ro 40-6890 is a broad spectrum antibiotic. The MIC(90) value against MSSA is 1mg/L and for E. coli 0.12mg/L. |
Description: | Hubschwerlen C, Charnas R, Angehrn P, et al. Ro 41-3399, a new oral Cephalosporin ester: synthesis and sructure- activity relations. 32nd-Intersci-Conf-Antimicrobial-Agents-Chemother 1992; 142 |
Institute where first reported: | Hoffmann-La Roche Inc, Switzerland |
Year first mentioned: | 1992 |
Highest developmental phase: | Phase 1 |
Development status: | Inactive |
Chemical structure(s): | |
Canonical SMILES: | CCC=C(COC(=O)C1=C(CN=[N+]=[N-])CSC2C(C(=O)N12)NC(=O)C(=NOC)C3=CSC(=N3)N)C(=O)OCC(C)C |
Isomeric SMILES: | CCC=C(COC(=O)C1=C(CSC2N1C(=O)C2NC(=O)C(=NOC)C3=CSC(=N3)N)CN=[N+]=[N-])C(=O)OCC(C)C |
InChI: | InChI=1S/C24H30N8O7S2/c1-5-6-13(22(35)38-8-12(2)3)9-39-23(36)18-14(7-27-31-26)10-40-21-17(20(34)32(18)21)29-19(33)16(30-37-4)15-11-41-24(25)28-15/h6,11-12,17,21H,5,7-10H2,1-4H3,(H2,25,28)(H,29,33) |
InChI Key: | FHPWLEQQFDSPCU-UHFFFAOYSA-N |
Structure link: | https://pubchem.ncbi.nlm.nih.gov/compound/78178403 |
External links: | |
Guide to Pharmacology: | Ro-406890 |
Main Source: | https://journals.asm.org/doi/10.1128/aac.36.12.2825?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed |