Compound ID | 444

Update compound information

Ceftrazonal bopentil

Synonym(s): Ro 41-3399

Class: Beta-lactam

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Cell wall synthesis inhibitor
Description: Prodrug/ orally active ester of Ro 40-6890; Hubschwerlen C, Charnas R, Angehrn P, et al. Ro 41-3399, a new oral Cephalosporin ester: synthesis and structure- activity relations. 32nd-Intersci-Conf-Antimicrobial-Agents-Chemother 1992; 142
Institute where first reported: Hoffmann-La Roche Inc, Switzerland
Year first mentioned: 1992
Highest development stage: Phase 1
Development status: Inactive
Chemical structure(s):
Click here for structure editor
Molecular weight: 606.68
Iso. SMILES: CCC=C(COC(=O)C1=C(CSC2N1C(=O)C2NC(=O)C(=NOC)C3=CSC(=N3)N)CN=[N+]=[N-])C(=O)OCC(C)C
InChI Key: FHPWLEQQFDSPCU-UHFFFAOYSA-N
Can. SMILES: CCC=C(COC(=O)C1=C(CN=[N+]=[N-])CSC2C(C(=O)N12)NC(=O)C(=NOC)C3=CSC(=N3)N)C(=O)OCC(C)C
InChI: InChI=1S/C24H30N8O7S2/c1-5-6-13(22(35)38-8-12(2)3)9-39-23(36)18-14(7-27-31-26)10-40-21-17(20(34)32(18)21)29-19(33)16(30-37-4)15-11-41-24(25)28-15/h6,11-12,17,21H,5,7-10H2,1-4H3,(H2,25,28)(H,29,33)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/78178403
Guide to Pharmacology: Ro-406890
Citation: https://journals.asm.org/doi/10.1128/aac.36.12.2825?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed

AntibioticDB is supported by GARDP.

If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.