Compound ID | 446

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E1101

Class: Beta-lactam

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Cell wall synthesis inhibitor
Description: Oral cephalosporin; 1. Inoue E, Nakane T and Mitsuhashi S. In vitro antibacterial activity and β-lactamase stability of E1101, a new Cephalosporin. 35th-Intersci-Conf-Antimicrobial-Agents-Chemother 1995; 119 2. Mikamo H, Kawazoe K, Izumi K, et al. Efficacy of a new oral Cephalosporin E1101 in the newly designed uterine endometritis model. 35th-Intersci-Conf-Antimicrobial-Agents-Chemother 1995; 120.
Institute where first reported: Eisai Co. Ltd, Japan
Year first mentioned: 1994
Highest development stage: Phase 2
Development status: Inactive
Chemical structure(s):
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Molecular weight: 600.62
Iso. SMILES: CC(C)OC(=O)OC(C)OC(=O)C1=C(CSC2N1C(=O)C2NC(=O)/C(=N\O)/C3=CSC(=N3)N)COC(=O)N(C)C
InChI Key: HCWUTKYREJUDHP-ZMFRSBBQSA-N
Can. SMILES: CC(C)OC(=O)OC(C)OC(=O)C1=C(COC(=O)N(C)C)CSC2C(C(=O)N12)NC(=O)/C(=N\O)/C3=CSC(=N3)N
InChI: InChI=1S/C22H28N6O10S2/c1-9(2)36-22(33)38-10(3)37-19(31)15-11(6-35-21(32)27(4)5)7-39-18-14(17(30)28(15)18)25-16(29)13(26-34)12-8-40-20(23)24-12/h8-10,14,18,34H,6-7H2,1-5H3,(H2,23,24)(H,25,29)/b26-13-
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9690119
Citation: https://doi.org/10.1159/000007131

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