Compound ID | 451
Dual Action Cephalosporin (DAC) PD 152915
Class: Cephalosporin-quinolone
| Spectrum of activity: | Gram-positive & Gram-negative |
| Details of activity: | The combination of Cephalosporin (cefuroxime, cephaloglycin or cephacetrile) linked to a pyrolidinyl and piperazinyl quinolone, these compounds were designed for oral absorption. Several cephacetrile derived compounds demonstrated oral efficiency active against E. coli and S. aureus |
| Description: | Vanderroest S, Gogliotti R, et al. Synthesis and antimicrobial activity of new dual action Cephalosporins (DACs) as potential oral agents. 35th-Intersci-Conf-Antimicrobial-Agents-Chemother 1995;117 |
| Institute where first reported: | Parke Davis Pharmaceutical Research (Pfizer, USA) |
| Year first mentioned: | 1995 |
| Highest developmental phase: | Preclinical |
| Development status: | Inactive |
| External links: | |
| Citation: |
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