Compound ID | 460

Update compound information

Coumamidine Gamma 1

Class: Coumamidine

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Unlike aminoglycosides, coumamidine has activity against anaerobic bacteria albeit weak activity.
Propensity to select resistant mutants: Low frequency of resistance
Institute where first reported: Abbott Laboratories
Year first mentioned: 1988
Development status: Inactive
Reason Dropped: Needs to be administered subcutaneously as not absorbed through oral administration(1)
Chemical structure(s):
Click here for structure editor
Molecular weight: 835.82
Iso. SMILES: CC1C(C(C(C(O1)OC2=CC=C(C=C2)/C=C/C(=O)NCCC(=N)N)N=C(N)N)O)NC(=O)NC3C(C(C(CO3)OC4COC5C(C4O)N(C(=O)N5)C(=O)N)O)NC(=O)N
InChI Key: RALPRAPANVNIPH-QPJJXVBHSA-N
Can. SMILES: CC1C(C(C(C(O1)OC2=CC=C(C=C2)/C=C/C(=O)NCCC(=N)N)N=C(N)N)O)NC(=O)NC3C(C(C(CO3)OC4COC5C(C4O)N(C(=O)N)C(=O)N5)O)NC(=O)N
InChI: InChI=1S/C33H49N13O13/c1-12-19(25(50)21(41-29(36)37)28(57-12)58-14-5-2-13(3-6-14)4-7-18(47)40-9-8-17(34)35)43-32(53)44-26-20(42-30(38)51)23(48)15(10-55-26)59-16-11-56-27-22(24(16)49)46(31(39)52)33(54)45-27/h2-7,12,15-16,19-28,48-50H,8-11H2,1H3,(H3,34,35)(H2,39,52)(H,40,47)(H,45,54)(H4,36,37,41)(H3,38,42,51)(H2,43,44,53)/b7-4+
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/6443955
Citations:
  • http://europepmc.org/abstract/MED/2498268

  • AntibioticDB is supported by GARDP.

    If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

    The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.