Compound ID | 465

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Diepoxin 1

Class: Diepoxin

Spectrum of activity: Gram-positive
Details of activity: No Gram negative activity was detectable but anti gram positive and anti-fungal activity was identified. Diepoxin 1 and 3 were seen to be between 2-4 times less effective than Diepoxin 4
Description: Pearce CJ, Katz B, Korshalla JD, Jacobus NV, et al. Diepoxins, novel antibiotics from fungus LL-07F275: I. Taxonomy, fermentation and biological activity. 33rd-Intersci-Conf-Antimicrobial-Agents-Chemother 1993; 224.
Institute where first reported: American cyanamid Co., USA
Year first mentioned: 1993
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 366.32
Iso. SMILES: C1CC(=O)[C@@]23[C@@]([C@H]1O)(O2)C(=O)[C@@H]4[C@H](C35OC6=CC=CC7=C6C(=CC=C7)O5)O4
InChI Key: KQMJFBCPPZURAP-MUKCLNALSA-N
Can. SMILES: C1=CC2=C3C(=C1)C=CC=C3OC4([C@H]5[C@@H](C(=O)[C@@]67[C@H](CCC(=O)[C@]64O7)O)O5)O2
InChI: InChI=1S/C20H14O7/c21-12-7-8-13(22)19-18(12,27-19)16(23)15-17(24-15)20(19)25-10-5-1-3-9-4-2-6-11(26-20)14(9)10/h1-6,12,15,17,21H,7-8H2/t12-,15+,17+,18-,19-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/139585239
Citations:
  • https://www.sciencedirect.com/science/article/pii/S0040403900792938
  • https://www.sciencedirect.com/science/article/pii/S0040403900792938

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