Compound ID | 476

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KRQ-10018

Class: Bacterial topoisomerase inhibitor

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Lower MICs than ciprofloxacin against S aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus epidermiditis and Enterobacter cloacae; DNA gyrase inhibitor
Description: Park T, Nam K, Ha Y, et al. Synthesis and antibacterial activity of KRQ-10018 and its analogues; potent DNA gyrase inhibitors. 37th-Intersci-Conf-Antimicrobial-Agents-Chemother 1997; 175.
Institute where first reported: Korea Research Institute of Chemical Technology, Korea
Year first mentioned: 1997
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 383.42
Iso. SMILES: CC1=C(N2CC3=CCCN[C@H]3C2)C(F)=CN4C(=O)C(C(=O)O)=CC(C5CC5)=C14
InChI Key: ATTWAJLIMNVEMY-KRWDZBQOSA-N
Can. SMILES: CC1=C(C(=CN2C1=C(C=C(C2=O)C(=O)O)C3CC3)F)N4CC5=CCCN[C@H]5C4
InChI: InChI=1S/C21H22FN3O3/c1-11-18-14(12-4-5-12)7-15(21(27)28)20(26)25(18)9-16(22)19(11)24-8-13-3-2-6-23-17(13)10-24/h3,7,9,12,17,23H,2,4-6,8,10H2,1H3,(H,27,28)/t17-/m0/s1
External links:
Citations:
  • https://journals.asm.org/doi/10.1128/aac.00897-07
  • https://journals.asm.org/doi/10.1128/aac.00897-07

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