Compound ID | 478

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WCK 919

Synonym(s): WCK-919

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: DNA synthesis inhibitor. DNA gyrase inhibitor
Description: Contains two chiral isomers: WCK 1152 and WCK 1153
Institute where first reported: Wockhardt, India
Year first mentioned: 2001
Development status: Experimental
Chemical structure(s):
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Molecular weight: 403.45
Iso. SMILES: COC1=C(N2CCC(N)C(C)(C)C2)C(F)=CC=3C(=O)C(C(=O)O)=CN(C4CC4)C13
InChI Key: PMBHAWNZPPNADR-UHFFFAOYSA-N
Can. SMILES: CC1(C)CN(CCC1N)C2=C(C3=C(C=C2F)C(=O)C(=CN3C4CC4)C(=O)O)OC
InChI: InChI=1S/C21H26FN3O4/c1-21(2)10-24(7-6-15(21)23)17-14(22)8-12-16(19(17)29-3)25(11-4-5-11)9-13(18(12)26)20(27)28/h8-9,11,15H,4-7,10,23H2,1-3H3,(H,27,28)
External links:
Citations:
  • https://www.sciencedirect.com/science/article/pii/S0960894X2200141X?via%3Dihub
  • https://doi.org/10.1016/j.bmcl.2022.128665

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