Compound ID | 485
HB-EMAU
Class: DNA polymerase III inhibitor (6-anilinouracils (dGTP analogue))
| Spectrum of activity: | Gram-negative |
| Details of activity: | Binds to and selectively inhibits DNA polymerase III of Gram positive eubacteria. It was tested against Gram positives resistant to fluoroquininolones, rifampin and vancomycin and demonstrated no cross resistance |
| Institute where first reported: | University of Massachusetts Medical School; GLSynthesis |
| Year first mentioned: | 1999 |
| Highest developmental phase: | Preclinical |
| Development status: | Inactive |
| Reason Dropped: | There was no in vivo activity and also the resistance frequency was not low enough (LS) |
| External links: | |
| PubChem link: | https://pubchem.ncbi.nlm.nih.gov/compound/10448521 |
| Citations: |
|
AntibioticDB is supported by GARDP.
If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions
The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.