Compound ID | 487

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MB-EMAU

Class: Nucleoside analogue

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: DNA synthesis inhibitor. DNA polymerase III inhibitor
Target Pathogen: Active against Staphylococcus aureus including coagulase-negative strains, Enterococcus faecium, and Enterococcus faecalis
Description: 6-Anilinouracil dGTP analogue (6-[3′-ethyl-4′-methylanilino]uracil) substituted with methoxybutyl group at N3 position
Institute where first reported: University of Massachusetts Medical School; GLSynthesis
Year first mentioned: 1999
Development status: Experimental
Chemical structure(s):
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Molecular weight: 331.41
Iso. SMILES: O=C1NC(NC2=CC=C(C)C(CC)=C2)=CC(N1CCCCOC)=O
InChI Key: JCIBXIZNDNUOLS-UHFFFAOYSA-N
Can. SMILES: CCC1=CC(=CC=C1C)NC2=CC(=O)N(CCCCOC)C(=O)N2
InChI: InChI=1S/C18H25N3O3/c1-4-14-11-15(8-7-13(14)2)19-16-12-17(22)21(18(23)20-16)9-5-6-10-24-3/h7-8,11-12,19H,4-6,9-10H2,1-3H3,(H,20,23)
External links:
Citations:
  • http://pubs.acs.org/doi/abs/10.1021/jm980693i
  • https://doi.org/10.1128/aac.44.8.2217-2221.2000

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