Compound ID | 488

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MB-IMAU

Class: DNA polymerase III inhibitor (6-anilinouracils (dGTP analogue))

Spectrum of activity: Gram-negative
Details of activity: DNA synthesis inhibitors; binds to and selectively inhibits DNA polymerase III of Gram positive eubacteria. It was tested against Gram positives resistant to fluoroquininolones, rifampin and vancomycin and demonstrated no cross resistance
Propensity to select resistant mutants: Yes
Institute where first reported: University of Massachusetts Medical School; GLSynthesis
Year first mentioned: 1999
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 429.25
Iso. SMILES: O=C1NC(NC2=CC=C(C)C(I)=C2)=CC(N1CCCCOC)=O
InChI Key: HIZXOBHUPWSQDK-UHFFFAOYSA-N
Can. SMILES: CC1=CC=C(C=C1I)NC2=CC(=O)N(CCCCOC)C(=O)N2
InChI: InChI=1S/C16H20IN3O3/c1-11-5-6-12(9-13(11)17)18-14-10-15(21)20(16(22)19-14)7-3-4-8-23-2/h5-6,9-10,18H,3-4,7-8H2,1-2H3,(H,19,22)
External links:
Citations:
  • http://pubs.acs.org/doi/abs/10.1021/jm980693i
  • https://journals.asm.org/doi/10.1128/aac.44.8.2217-2221.2000?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed
  • https://journals.asm.org/doi/10.1128/aac.44.8.2217-2221.2000?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed

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