Compound ID | 495

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MF-961

Class: Fluoroquinolone (rufloxacin derivative)

Spectrum of activity: Gram-positive
Details of activity: 2 fold more active than rufloxacin and 4-16 times less active than norfloxacin
Propensity to select resistant mutants: A comparison against ofloxacin, fleroxacin and rufloxacin yielded the least resistant mutants
Institute where first reported: University of Birmingham, UK
Year first mentioned: 1989
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 395.43
Iso. SMILES: CN1CCN(CC1)C2=C(C=C3C4=C2SCC(N4C=C(C3=O)C(=O)O)CF)F
InChI Key: YHMYZZSLDKKBQL-UHFFFAOYSA-N
Can. SMILES: CN1CCN(CC1)C2=C3C4=C(C=C2F)C(=O)C(=CN4C(CF)CS3)C(=O)O
InChI: InChI=1S/C18H19F2N3O3S/c1-21-2-4-22(5-3-21)15-13(20)6-11-14-17(15)27-9-10(7-19)23(14)8-12(16(11)24)18(25)26/h6,8,10H,2-5,7,9H2,1H3,(H,25,26)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/124046
Citations:
  • http://www.ncbi.nlm.nih.gov/pubmed/1324239

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