Compound ID | 498

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DX-619

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: DNA synthesis inhibitor. Type II topoisomerase, gyrase, and topoisomerase IV inhibitor
Target Pathogen: Active against Staphylococcus aureus
Institute where first reported: Daiichi Pharmaceutical Co., Ltd (Daiichi Sankyo Pharmaceutical, Japan)
Year first mentioned: 2003
Highest development stage: Phase 1
Development status: Inactive
Chemical structure(s):
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Molecular weight: 401.43
Iso. SMILES: COC1=C(C=CC2=C1N(C=C(C2=O)C(=O)O)[C@@H]3C[C@@H]3F)N4CC[C@H](C4)C5(CC5)N
InChI Key: ZLICIITZJTYKAQ-DIOULYMOSA-N
Can. SMILES: COC1=C2C(=CC=C1N3CC[C@H](C3)C4(CC4)N)C(=O)C(=CN2[C@@H]5C[C@@H]5F)C(=O)O
InChI: InChI=1S/C21H24FN3O4/c1-29-19-15(24-7-4-11(9-24)21(23)5-6-21)3-2-12-17(19)25(16-8-14(16)22)10-13(18(12)26)20(27)28/h2-3,10-11,14,16H,4-9,23H2,1H3,(H,27,28)/t11-,14+,16-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9865774
Guide to Pharmacology: DX-619
Citation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1315973/

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