Compound ID | 507

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WQ-2756

Class: Fluoroquinolone

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Upon infection of quinolone resistant- S. aureus into mice the effective dose was 7.8mg/kg in comparison to tosufloxacin with >100mg/ml
Description: Hayashi N, Amano H, Ohshita Y, et al. In vitro and in vivo acctivities, pharmacokinetics and toxicity of WQ-2756 and WQ-2765.
Institute where first reported: Wakunaga Pharmaceuticals, Japan
Year first mentioned: 1996
Highest developmental phase: Preclinical
Development status: Inactive
Reason Dropped: Poor pharmokinetics
Chemical structure(s):
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Molecular weight: 438.79
Iso. SMILES: C1C(CN1C2=C(C=C3C(=C2Cl)N(C=C(C3=O)C(=O)O)C4=C(C=C(C(=C4)N)F)F)F)N
InChI Key: ATHBCDQPZRXUNJ-UHFFFAOYSA-N
Can. SMILES: C1=C(C(=C(C2=C1C(=O)C(=CN2C3=CC(=C(C=C3F)F)N)C(=O)O)Cl)N4CC(C4)N)F
InChI: InChI=1S/C19H14ClF3N4O3/c20-15-16-8(1-12(23)17(15)26-4-7(24)5-26)18(28)9(19(29)30)6-27(16)14-3-13(25)10(21)2-11(14)22/h1-3,6-7H,4-5,24-25H2,(H,29,30)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9803202
Citation:

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