Compound ID | 511

Update compound information

BMY 40062

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: DNA synthesis inhibitor
Target Pathogen: Active against staphylococci, streptococci, and enterococci
Description: A fluoronaphthyridone
Institute where first reported: Bristol Myers Research Institute, Ltd., Tokyo, Japan
Year first mentioned: 1988
Development status: Experimental
Reason dropped: Resistance builds up quickly, was also cross resistant with other fluoroquinolones
Chemical structure(s):
Click here for structure editor
Molecular weight: 360.38
Iso. SMILES: CC(C)(C)N1C=C(C(=O)C2=CC(=C(N=C21)N3C[C@H]4C[C@@H]3CN4)F)C(=O)O
InChI Key: KNHLHFDFFDCJJR-NXEZZACHSA-N
Can. SMILES: CC(C)(C)N1C=C(C(=O)C2=C1N=C(C(=C2)F)N3C[C@H]4C[C@@H]3CN4)C(=O)O
InChI: InChI=1S/C18H21FN4O3/c1-18(2,3)23-8-12(17(25)26)14(24)11-5-13(19)16(21-15(11)23)22-7-9-4-10(22)6-20-9/h5,8-10,20H,4,6-7H2,1-3H3,(H,25,26)/t9-,10-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/163995
Citations:
  • http://link.springer.com/article/10.1007/BF01967221#
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC284253/

    • AntibioticDB is supported by GARDP.

    If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

    The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.