KB-5246

Class: Fluoroquinolone (tetracyclic quinolone)

Spectrum of activity:	Gram-positive  &  Gram-negative
Institute where first reported:	Kanebo; Nippon Organon
Year first mentioned:	1988
Highest developmental phase:	Phase 1 (2)
Development status:	Inactive
Reason Dropped:	Phase I studies in progress after animal trials showed lower concentrations required (mg/kg aginast body mass) in mice (1).

Chemical structure(s):
Canonical SMILES:	CN1CCN(CC1)C2=C3C4=C(C=C2F)C(=O)C(=C5N4C(=CS5)CO3)C(=O)O.Cl
Isomeric SMILES:	CN1CCN(CC1)C2=C(C=C3C4=C2OCC5=CSC(=C(C3=O)C(=O)O)N54)F.Cl
InChI:	InChI=1S/C18H16FN3O4S.ClH/c1-20-2-4-21(5-3-20)14-11(19)6-10-13-16(14)26-7-9-8-27-17(22(9)13)12(15(10)23)18(24)25;/h6,8H,2-5,7H2,1H3,(H,24,25);1H
InChI Key:	YNPLQSCXSPGFPU-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/6918093

External links:
Guide to Pharmacology:	KB-5246
Citations:	http://aac.asm.org/content/33/11/1896.long http://www.chemdrug.com/article/8/3285/16420781.html