Compound ID | 515

Update compound information

Clinafloxacin

Synonym(s): AM 1091  |  CI-960  |  PD 127,391  |  PD 127391

Class: Fluoroquinolone

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: An analogue of ciprofloxacin designed for enhanced activity against Gram positives (1). This is effective against multi drug resistant infections (2)
Institute where first reported: Pfizer, USA
Year first mentioned: 1986
Highest developmental phase: Phase 3
Development status: Inactive
Reason Dropped: Due to concerns of adverse effects, this was discontinued at registration phase. However, according to AdisInsight this may become marketed later as Pfizer are seeking compassionate designation usage as this was for a last lline defense (1)
Chemical structure(s):
Click here for structure editor
Molecular weight: 365.79
Iso. SMILES: C1CC1N2C=C(C(=O)C3=CC(=C(C(=C32)Cl)N4CCC(C4)N)F)C(=O)O
InChI Key: QGPKADBNRMWEQR-UHFFFAOYSA-N
Can. SMILES: C1CC1N2C=C(C(=O)C3=C2C(=C(C(=C3)F)N4CCC(C4)N)Cl)C(=O)O
InChI: InChI=1S/C17H17ClFN3O3/c18-13-14-10(5-12(19)15(13)21-4-3-8(20)6-21)16(23)11(17(24)25)7-22(14)9-1-2-9/h5,7-9H,1-4,6,20H2,(H,24,25)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/60063
Guide to Pharmacology: clinafloxacin
Citations:
  • http://aac.asm.org/content/45/9/2543.full
  • http://adisinsight.springer.com/drugs/800000525

  • AntibioticDB is supported by GARDP.

    If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

    The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.