Compound ID | 521

Update compound information

MC-04124

Class: Efflux pump inhibitor

Details of activity: Permeates bacteria to other antibiotic compounds; greatly enhances activity of macolides against Gram negative bacteria
Institute where first reported: Microcide Pharmaceuticals; (Essential Therapeutics (Ceased))
Year first mentioned: 2000
Highest developmental phase: Preclinical
Development status: Inactive
Reason Dropped: Essential Therapeutics closed down in 2004
Chemical structure(s):
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Molecular weight: 431.53
Iso. SMILES: C1[C@@H](CN[C@H]1C(=O)N[C@H](CCC2=CC=CC=C2)C(=O)NC3=CC4=C(C=C3)N=CC=C4)CN
InChI Key: MWHIVLDZWWNQPL-SXSPYAJSSA-N
Can. SMILES: C1=CC=C(C=C1)CC[C@H](C(=O)NC2=CC=C3C(=C2)C=CC=N3)NC(=O)[C@H]4C[C@H](CN)CN4
InChI: InChI=1S/C25H29N5O2/c26-15-18-13-23(28-16-18)25(32)30-22(10-8-17-5-2-1-3-6-17)24(31)29-20-9-11-21-19(14-20)7-4-12-27-21/h1-7,9,11-12,14,18,22-23,28H,8,10,13,15-16,26H2,(H,29,31)(H,30,32)/t18-,22-,23-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/6918608
Citation:

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