Compound ID | 522

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MC-207,110

Synonym(s): MC 207110  |  MC207110  |  MC-207110

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Efflux pump inhibitor
Target Pathogen: Active against Pseudomonas aeruginosa efflux pumps
Combined with other compounds: Needs to be coupled with another antibiotic compound
Institute where first reported: Microcide Pharmaceuticals; (Essential Therapeutics (Ceased)); Daiichi Sankyo Pharmaceutical, Japan; Essential Therapeutics (Ceased)
Year first mentioned: 2000
Development status: Experimental
Reason dropped: Essential Therapeutics closed down in 2004
Chemical structure(s):
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Molecular weight: 519.47
Iso. SMILES: C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC2=CC3=CC=CC=C3C=C2)N.Cl.Cl
InChI Key: MRUMOHLDHMZGMS-IXOXMDGESA-N
Can. SMILES: C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC2=CC3=C(C=CC=C3)C=C2)N.Cl.Cl
InChI: InChI=1S/C25H30N6O2.2ClH/c26-21(15-17-7-2-1-3-8-17)23(32)31-22(11-6-14-29-25(27)28)24(33)30-20-13-12-18-9-4-5-10-19(18)16-20;;/h1-5,7-10,12-13,16,21-22H,6,11,14-15,26H2,(H,30,33)(H,31,32)(H4,27,28,29);2*1H/t21-,22-;;/m0../s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/90665180
Citation: https://doi.org/10.1128/aac.45.1.105-116.2001

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