Compound ID | 526

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MC 02595

Synonym(s): MC-02,595  |  D-orn-D-hPhe-3NHQ

Class: Efflux pump inhibitor

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Permeates bacteria to other antibiotic compounds; pseudomonal infections
Combined with other compounds: Tested with Levofloxacin and results were positive
Institute where first reported: Microcide Pharmaceuticals (Essential Therapeutics (Ceased)); Daiichi Sankyo Pharmaceutical, Japan
Year first mentioned: 2000
Highest developmental phase: Preclinical
Development status: Inactive
Reason Dropped: Essential Therapeutics closed down in 2004
Chemical structure(s):
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Molecular weight: 419.52
Iso. SMILES: NCCCC(N)C(=O)NC(CCC1=CC=CC=C1)C(=O)NC2=CN=C3C=CC=CC3=C2
InChI Key: KUXYCYLURMIFID-UHFFFAOYSA-N
Can. SMILES: C1=CC=C(C=C1)CCC(C(=O)NC2=CC3=C(C=CC=C3)N=C2)NC(=O)C(CCCN)N
InChI: InChI=1S/C24H29N5O2/c25-14-6-10-20(26)23(30)29-22(13-12-17-7-2-1-3-8-17)24(31)28-19-15-18-9-4-5-11-21(18)27-16-19/h1-5,7-9,11,15-16,20,22H,6,10,12-14,25-26H2,(H,28,31)(H,29,30)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/substance/273137022
Citation: https://www.sciencedirect.com/science/article/pii/S0960894X03005560?via%3Dihub

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