Compound ID | 532
RU 75411
Synonym(s): Riburamycin
Class: MraY inhibitor (nucleoside)
| Spectrum of activity: | Gram-negative |
| Details of activity: | Interferes with cell-wall synthesis by inhibiting transfer of the peptidoglycan precursor moiety (MurNAc-pentapeptide) to the membrane lipid carrier, undecaprenyl phosphate. |
| Institute where first reported: | Aventis (Sanofi-Aventis, France) |
| Year first mentioned: | 2002 |
| Highest developmental phase: | Preclinical |
| Development status: | Inactive |
| Reason Dropped: | Another MraY inhibitor - stops cell wall synthesis. These uracil-containing [natural products and natural product derivative] compounds generally select for rapid resistance due to loss of transport.- (LS) |
| External links: | |
| Structure link: | See source publication |
| Citation: | https://www.drugfuture.com/synth/syndata.aspx?ID=312812 |
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