Compound ID | 533

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MUT37307

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Fatty acid synthesis inhibitor. FabI inhibitor
Description: A non-biocidal triclosan derivative; Escaich S, Prouvensier L, Saccomani M, et al. MUT37307 FabI inhibitor: in vitro and in vivo antibacterial activity against Staphylococcal aureus. 48-ICAAC-46-IDSA-2008 2008;278
Institute where first reported: Mutabilis (Fab Pharma., France)
Year first mentioned: 2008
Development status: Experimental
Chemical structure(s):
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Molecular weight: 251.23
Iso. SMILES: CCC1=CC(=C(C=C1F)OC2=C(N=CC=C2)F)O
InChI Key: BJEMGBNLIALWCL-UHFFFAOYSA-N
Can. SMILES: CCC1=C(C=C(C(=C1)O)OC2=CC=CN=C2F)F
InChI: InChI=1S/C13H11F2NO2/c1-2-8-6-10(17)12(7-9(8)14)18-11-4-3-5-16-13(11)15/h3-7,17H,2H2,1H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/25020641
Citations:
  • https://doi.org/10.1021/bi5014358
  • https://pubs.acs.org/doi/10.1021/jm301113w

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