Compound ID | 539

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A-80556 (A-65326.HCL)

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: DNA synthesis inhibitor
Description: Chu DTW, Li Q, Tanaka K, et al. Synthesis and biological properties of A-80556: a potent antibacterial fluoroaryllquinolone. 32nd-Intersci-Conf-Antimicrobial-Agents-Chemother 1992; 219.
Institute where first reported: Abbott Laboratories, USA
Year first mentioned: 1992
Development status: Experimental
Chemical structure(s):
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Molecular weight: 417.38
Iso. SMILES: C[C@H]1C[C@@H](CN1C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=C(C=C(C=C4)F)F)F)N
InChI Key: CQSCBORSOIETFL-JQWIXIFHSA-N
Can. SMILES: C[C@H]1C[C@@H](CN1C2=CC3=C(C=C2F)C(=O)C(=CN3C4=CC=C(C=C4F)F)C(=O)O)N
InChI: InChI=1S/C21H18F3N3O3/c1-10-4-12(25)8-26(10)19-7-18-13(6-16(19)24)20(28)14(21(29)30)9-27(18)17-3-2-11(22)5-15(17)23/h2-3,5-7,9-10,12H,4,8,25H2,1H3,(H,29,30)/t10-,12-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/468954
Citation: https://journals.asm.org/doi/10.1128/aac.38.5.1071

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