Compound ID | 543

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DC 756

Synonym(s): DC-756

Class: Fluoroquinolone

Spectrum of activity: Gram-positive
Details of activity: Low toxicity in mice with LD(50)~150mg/kg with potent activity against quinolone resistant MRSA, S. epidermidis, S. pneumoniae and E. faecalis.
Description: Yabe K, Murakami Y, Yamamoto N, et al. DC-756: a new methoxyquinolone: toxicological and pharmacokinetic evaluation. 38th-Intersci-Conf-Antimicrobial-Agents-Chemother 1998; 250.
Institute where first reported: Daiichi Pharmaceutical Co. Ltd., Japan
Year first mentioned: 1998
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 393.39
Iso. SMILES: COC1=C2C(=CC(=C1N3C[C@@H]([C@@H](C3)N)CF)F)C(=O)C(=CN2C4CC4)C(=O)O
InChI Key: XGZPDXTUAWRGLD-LKFCYVNXSA-N
Can. SMILES: COC1=C(C(=CC2=C1N(C=C(C2=O)C(=O)O)C3CC3)F)N4C[C@H](CF)[C@@H](C4)N
InChI: InChI=1S/C19H21F2N3O4/c1-28-18-15-11(17(25)12(19(26)27)7-24(15)10-2-3-10)4-13(21)16(18)23-6-9(5-20)14(22)8-23/h4,7,9-10,14H,2-3,5-6,8,22H2,1H3,(H,26,27)/t9-,14+/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9843521
Citation:

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