Compound ID | 544

Update compound information

DQ-113

Synonym(s): D 611113  |  D61-1113

Class: Fluoroquinolone

Spectrum of activity: Gram-positive
Details of activity: Active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus sp., and penicillin-resistant Streptococcus pyogenes
Propensity to select resistant mutants:
Institute where first reported: Daiichi Sankyo Pharmaceutical, Japan
Year first mentioned: 2000
Highest developmental phase: Preclinical
Development status: Experimental
Reason Dropped: This had relatively high resistance development (LS, 2)
Chemical structure(s):
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Molecular weight: 436.43
Iso. SMILES: CC1=C2C(=C(C(=C1N3C[C@@H]([C@@H](C3)F)C4(CC4)N)F)N)C(=O)C(=CN2[C@@H]5C[C@@H]5F)C(=O)O
InChI Key: QEYBPFUVEMVIQD-WUHRBBMRSA-N
Can. SMILES: CC1=C(C(=C(C2=C1N(C=C(C2=O)C(=O)O)[C@@H]3C[C@@H]3F)N)F)N4C[C@@H]([C@@H](C4)F)C5(CC5)N
InChI: InChI=1S/C21H23F3N4O3/c1-8-17-14(19(29)9(20(30)31)5-28(17)13-4-11(13)22)16(25)15(24)18(8)27-6-10(12(23)7-27)21(26)2-3-21/h5,10-13H,2-4,6-7,25-26H2,1H3,(H,30,31)/t10-,11-,12+,13+/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/493409
Citations:
  • http://aac.asm.org/content/51/4/1512.full.pdf
  • https://journals.asm.org/doi/10.1128/aac.46.3.904-908.2002

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